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KMID : 0882420110800060723
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Korean Journal of Medicine
2011 Volume.80 No. 6 p.723 ~ p.728
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A Case of Bilateral Acute Renal Cortical Necrosis Complicated by Tranexamic Acid Administration
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Park Joo-Ho
Kang Min-Kyu
Na Woon-Tae
Song In-Girl
Jung Jang-Han
Yoon Se-Hee
Yun Sung-Ro
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Abstract
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Acute renal cortical necrosis is an anuric form of acute renal failure. We experienced a case of renal cortical necrosis complicated by tranexamic acid administration. To our knowledge, only three cases of renal cortical necrosis have been reported worldwide. A 49-year-old man was referred with hemothorax and multiple bone fractures following a traffic accident. Tranexamic acid, and hemocoagulase were injected three times a day. After the 4th dose of hemostatics, anuria developed abruptly, the platelet count decreased to 84,000 /μL, and the serum creatinine was increased to 2.56 from 1.06 mg/dL. On the 4th Intensive Care Unit (ICU) day, computed tomography (CT) showed bilateral renal cortical necrosis with normal renal arteries and aorta. The oliguria persisted for 14 days and temporary hemodialysis was performed. The serum creatinine had decreased to 2.12 mg/dL 8 months after discharge.
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KEYWORD
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Kidney cortex necrosis, Tranexamic acid, Acute kidney failure, Anuria
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